Product Name: Afoxolaner Chewable Tablets
Indication: For the prevention and treatment of common internal and external parasitic infections in dogs and ats.
Effectively kills and prevents fleas (Ctenocephalides felis, C. canis) and ticks (e.g., Ixodes ricinus,
Rhipicephalus sanguineus). Breaks the flea life cycle to prevent reproduction.
Treats and controls roundworms (e.g., Toxocara canis, T. cati), hookworms, and whipworms; prevents
heartworm disease (Dirofilaria immitis); treats tapeworm infections (e.g., Dipylidium caninum, Taenia
pisiformis).
Dosage: For oral use only.
For oral administration. Once monthly.
Select the tablet strength that most closely matches the pet’s current body weight. May be administered with or without food.
| Body weight of pets (kg) | Body Weight (kg) |
| 2.0<BW≤4.0 | 11.3mg |
| 4.0<BW≤10.0 | 28.3mg |
| 10.0<BW≤25.0 | 68mg |
| 25.0<BW≤50.0 | 136mg |
Withdrawal:
Not applicable
Package:
30 tablets per bottle
Storage:
Store tightly sealed below 25℃
Shelf life: 2 years
Warning：
This product contains a highconcentration, last-resort antibiotic. Accidental ingestion by humans may cause serious health effects and contribute to antibiotic resistance. Seek medical advice immediately if ingested.
Important Notes
(1)Prescription-only: This is a prescription-only medicine. Administration MUST be under the direct supervision and guidance of a veterinarian.
(2)Complete the Course: Even if symptoms improve, administer the full course as prescribed to prevent relapse and resistance development.
(3)Monitoring: Regular monitoring of renal function and overall clinical response is essential during treatment.
(4)Adverse Reactions: Potential side effects may include vomiting, diarrhea, loss of appetite, or in rare cases neurological signs (e.g.,tremors). Discontinue use and contact your veterinarian immediately if adverse reactions occur.
(5)THERAPEUTIC WARNING: While this product is a specific antiviral agent, the successful management of feline panleukopenia critically depends on timely and aggressive supportive care to address dehydration, secondary infections, and nutritional support. This product does not replace essential
fluid and electrolyte therapy.
Product Name: Fluralaner Chewable Tablets
Indication: For the treatment and prevention of flea and tick infestations in dogs.
A single dose provides continuous protection for up to 12 weeks.
Begins killing fleas within 2 hours, with >95% efficacy within 24 hours.
Kills Ctenocephalides felis and C. canis, and aids in the control of Flea Allergy Dermatitis (FAD).
Effective against multiple tick species, including but not limited to Ixodes ricinus, Rhipicephalus sanguineus,
Ixodes scapularis, and Amblyomma americanum.
Breaks the flea life cycle by killing adult fleas, thereby helping to control the environmental flea population.
Dosage: For oral use only.
Oral administration. Once every 12 weeks.
Select the tablet strength that most closely matches the pet’s current body weight. May be administered with or without food.
| Body weight of pets (kg) | Dosage per Administration |
| 2.<BW≤4.5 | 112.5mg |
| 4.5<BW≤10.0 | 250mg |
| 10.0<BW≤20.0 | 500mg |
| 20.0<BW≤40.0 | 1000mg |
| 40.0<BW≤56.0 | 1400mg |
| BW>56 | Use a combination of pipettes |
Precautions
1.This is a prescription drug and must be used under
veterinary supervision
2.Do not use in dogs under 8 weeks of age or
weighing less than 2.0 kg
3.Do not use in cats under 8 weeks of age or
weighing less than 1.2 kg
4.Use with caution in dogs with a history of seizures
or neurological disorders
5.The safety of fluralaner has not been established in
breeding, pregnant, or lactating animals
6.Keep out of reach of children
Package:
1 tablet per blister, 1 blister per box
Aluminum-plastic blister pack
Storage:
Store tightly sealed below 30°C, protected from
light and moisture
Shelf life: 2 years
Mechanism of Action
Fluralaner is a systemic insecticide and acaricide of the isoxazoline class. It inhibits gammaaminobutyric acid-gated chloride channels and Lglutamate-gated chloride channels in arthropods, leading to uncontrolled nerve activity and death of fleas and ticks. Fleas and ticks must attach to the host and commence feeding to be exposed to the active substance.
Drug Interactions
No clinically significant drug interactions have been identified
Concomitant use with other isoxazoline class parasiticides may increase the risk of neurological
adverse reactions
For animal use only.
Product Name: Fluralaner Chewable Tablets
Indication: For the treatment and prevention of flea and tick infestations in dogs.
A single dose provides continuous protection for up to 12 weeks.
Begins killing fleas within 2 hours, with >95% efficacy within 24 hours.
Kills Ctenocephalides felis and C. canis, and aids in the control of Flea Allergy Dermatitis (FAD).
Effective against multiple tick species, including but not limited to Ixodes ricinus, Rhipicephalus sanguineus, Ixodes scapularis, and Amblyomma americanum.
Breaks the flea life cycle by killing adult fleas, thereby helping to control the environmental flea population.
Dosage: For oral use only.
Oral administration. Once every 12 weeks.
Select the tablet strength that most closely matches the pet’s current body weight. May be administered with
or without food.
| Body weight of pets (kg) | Dosage per Administration |
| 2.8<BW≤6.0 | 112.5mg |
| 6.0<BW≤12.0 | 250mg |
| 12.0<BW≤24.0 | 500mg |
| 24.0<BW≤48.0 | 1000mg |
| 48.0<BW≤56.0 | 1400mg |
Withdrawal:
Not applicable
Package:
30 tablets per bottle
Storage:
Store tightly sealed below 25℃
Shelf life: 2 years
Warning：
This product contains a highconcentration, last-resort antibiotic.
Accidental ingestion by humans may cause serious health effects and contribute to antibiotic resistance. Seek medical advice immediately if ingested.
Important Notes
(1)Prescription-only: This is a prescription-only medicine. Administration MUST be under the direct supervision and guidance of a veterinarian.
(2)Complete the Course: Even if symptoms improve, administer the full course as prescribed to prevent relapse and resistance development.
(3)Monitoring: Regular monitoring of renal function and overall clinical response is essential during treatment.
(4)Adverse Reactions: Potential side effects may include vomiting, diarrhea, loss of appetite, or in rare cases neurological signs (e.g., tremors). Discontinue use and contact your veterinarian immediately if adverse reactions occur.
(5)THERAPEUTIC WARNING: While this product is a specific antiviral agent, the successful management of feline panleukopenia critically depends on timely and aggressive supportive care to address dehydration, secondary infections, and nutritional support. This product does not replace essential fluid and electrolyte therapy.
For animal use only.
Product Name: Fluralaner Solution
Indication: For the treatment and control of parasitic infestations in production animals.
Treatment and control of red mite (Dermanyssus gallinae) infestations
Treatment and control of northern fowl mite (Ornithonyssus sylviarum)
Treatment of scaly leg mite (Knemidocoptes mutans)
Treatment and control of lice
Treatment of ear mites
Dosage:
Administration via drinking water:
0.05 mL/kg body weight (equivalent to 0.5 mg fluralaner/kg
body weight).
Administer once every 7 days for a total of 2 doses.Daily dosage calculation (mL/day):
Total estimated body weight of the animal (kg) × 0.05 mL/kg.
Example: 1 L of this product can treat with a total body weight
of 20,000 kg
Administration Instructions
1.Prepare fresh medicated drinking water daily
2.Ensure all animals have access to medicated water for the entire treatment period
3.Do not provide unmedicated water during treatment days
4.Clean water lines before and after treatment
5.Treat for 2 consecutive days; repeat after 3-4 weeks if necessary
Mechanism of Action
Fluralaner is a systemic insecticide and acaricide of the isoxazoline class. It inhibits gamma-aminobutyric
acid-gated chloride channels and L-glutamate-gated chloride channels in arthropods, leading to
uncontrolled nerve activity and death of parasites. The product is absorbed via the gastrointestinal tract
after oral administration and distributes systemically to reach parasites feeding on the host.
Adverse Reactions
In rare cases:
Temporary decrease in water consumption (due to taste)
Mild gastrointestinal upset (diarrhea)
Most reactions are mild and self-limiting
Precautions
1.This is a veterinary prescription drug and must be used under veterinary supervision
2.Do not use in animals intended for human consumption within the withdrawal period
3.Observe the specified withdrawal period before slaughter
4.Do not use in animals with known hypersensitivity to isoxazoline compounds
5.Avoid contamination of feed and water sources
6.Wear protective gloves when handling the concentrated solution
7.Keep out of reach of children
Environmental Precautions
Do not contaminate ponds, waterways, or ditches with the product or used containers
Dispose of empty containers according to local regulations
This product is toxic to aquatic organisms
Package:
100ml, 500ml, 1L, 5L, 20L HDPE bottles
Storage:
Store tightly sealed below 30°C, protected from light. Do not freeze.
Shelf life: 2 years(opened: use within 3 months)
For animal use only.
Product Name: Fluralaner Topical Solution (Pour-On)
Indication: For the prevention and treatment of infestations caused by New World screwworm (Cochliomyia hominivorax) larvae (myiasis) and treatment and control of cattle fever tick (Rhipicephalus microplus) in beef cattle 2 months of age and older and replacement dairy heifers less than 20 months of age.
For Use In:Beef cattle 2 months of age and older; replacement dairy heifers less than 20 months of age
Not for use in: Bulls intended for breeding 1 year of age and older, dairy calves, veal calves, and female dairy cattle 20 months of age or older (including dry dairy cows).
Dosage:
| Parameter | Value |
| Dosage | 1 mL per 44.1 lbs (1 mL per 20 kg) body weight |
| Equivalent | 2.5 mg fluralaner per kg body weight |
| Route | Topical (pour-on) |
| Frequency | Single administration |
| Body Weight (lbs) | Body Weight (kg) | Dose Volume (mL) |
| 220 | 100 | 5 |
| 330 | 150 | 7.5 |
| 440 | 200 | 10 |
| 550 | 250 | 12.5 |
| 660 | 300 | 15 |
| 770 | 350 | 17.5 |
| 880 | 400 | 20 |
| 990 | 450 | 22.5 |
| 1100 | 500 | 25 |
| 1320 | 600 | 30 |
For body weight above 1320 lbs (600 kg): Add 2.5 mL for each additional 110 lbs (50 kg).
Administration Instructions
Apply in a narrow strip along the dorsal midline from the withers to the base of the tail.
1.Hold the bottle upright and at eye level – slowly squeeze the bottle to fill the dosing chamber to the selected mark
2.Pour the measured volume along the dorsal midline from withers to tail base
3.A small amount of liquid will remain on the chamber walls (chamber is calibrated to account for this)
4.Avoid squeezing the container while pouring from the dosing chamber
Mechanism of Action
Fluralaner belongs to the class of isoxazoline-substituted benzamide derivatives. It inhibits the arthropod
nervous system by antagonizing ligand-gated chloride channels (GABA-receptor and glutamate-receptor), leading to uncontrolled nerve activity and death of parasites.
Withdrawal Period
| Condition | Withdrawal Period |
| General | 98 days post-treatment |
| Continuous exposure to ≥60°F (≥15.5°C) after treatment | 44 days post-treatment |
Warning: Violative residues may result if cattle are exposed to temperatures below 60°F after administration and are slaughtered at 44 days.
Environmental Precautions
Do not contaminate ponds, waterways, or ditches with the product or used containers
Dispose of empty containers according to local regulations
This product is toxic to aquatic organisms
Package:
100ml, 500ml, 1L, 5L, 20L HDPE bottles
Storage:
Store tightly sealed below 30°C, protected from light. Do not freeze.
Shelf life: 2 years(opened: use within 6 months)
For animal use only.